Languages by language family/Isolated deaf sign
- (Do not confuse with auxiliary sign systems, rural (or village) sign languages, and family sign languages.)
- Afghan Sign Language [afg] (disabled)
- Al-Sayyid Bedouin Sign Language (or ABSL) [syy] (disabled)
- Albanian Sign Language (or AlbSL, Gjuha e Shenjave Shqipe, GSS) [sqk] (disabled)
- Angami Naga (or Naga Hills) Sign Language [?] (disabled)
- Argentine Sign Language (or Lengua de sinais Argentina, LSA) [aed] (disabled)
- Azerbaijani Sign Language (or Azərbaycan işarət dili, AİD) [?] (disabled)
- Belizean Sign Language [?] (disabled)
- Bhutanese Sign Language [?] (disabled)
- Brazilian Sign Language (or São Paulo Sign Language, Língua de sinais Brasileira, LSB, Libras, Língua gestual Brasileira, LGB, Língua de Sinais das Cidades Brasileiras, LSCB) [bzs] (disabled)
- Burkina Sign Language (or Langue des signes burkinabé, Langue des signes mossi, Mossi Sign Language) [?] (disabled)
- Cambodian Sign Language (or CBDSL, CSL, Khmer Sign Language, KSL) [csx] (disabled)
- Cuban Sign Language (or Lengua de señas cubana, LSC) [csf] (disabled)
- Ecuadorian Sign Language (or LSEC) [ecs] (disabled)
- Estonian Sign Language (or Eesti Viipekeel, EVK) [eso] (disabled)
- Guatemalan Sign Language (or Lensegua, Língua gestual da Guatemala, LGG) [gsm] (disabled)
- Guinea-Bissau Sign Language (or GBSL) [lgs] (disabled)
- Hausa Sign Language (or Maganar Bebaye, Maganar Hannu, Língua gestual Hausa, LGH) [hsl] (disabled)
- Kurdish Sign Language [?] (disabled)
- Macedonian Sign Language [?] (disabled)
- Malian Sign Language (or Mali Sign Language, Langue des signes malienne, LaSiMa, LSM, Langue des signes bambara, Bamako Sign Language) [bog] (disabled)
- Maltese Sign Language (or LSM) [mdl] (disabled)
- Mauritian Sign Language (or MSL) [lsy] (disabled)
- Mozambican Sign Language [mzy] (disabled)
- Nicaraguan Sign Language (or Idioma de señas de Nicaragua, ISN) [ncs] (disabled)
- Ottoman (or Seraglio, Harem) Sign Language (†) [?] (disabled)
- Penang Sign Language [psg] (disabled)
- Rwandan Sign Language (or Kinyarwandan Sign Language, Amarenga y’Ikinyarwanda, AKR, Amarenga yo mu Rwanda, AMR) [rsn]
- Sri Lankan Sign Language [sqs] (disabled)
- Tanzanian Sign Language (or Lugha Ya Bubu, Lugha Ya Alama) [tza] (disabled)
- Tibetan Sign Language (or Bökyi lagda) [lsn] (disabled)
- Turkish Sign Language (or Türk İşaret Dili) [tsm] (disabled)
- Yoruban Sign Language (YSL) (disabled)
- Zaban Eshareh Irani (or Persian Sign Language, Iranian Sign Language) [psc] (disabled)
- Zairian Sign Language (or Langue des signes congolaise, Congolese Sign Language, Langue des signes zaïroise, LSZ) [?] (disabled)
- Zambian Sign Language (or ZSL) [zsl] (disabled)
- Zimbabwe Sign Language (or Zimsign) [zib] (disabled)
- Kenya-Somali Sign Language [xki] (disabled)
- Kenyan Sign Language (or KSL, Swahili Sign Language, LAK, Língua gestual queniana, LGQ)
- Somali Sign Language (SSL)
- Plains Indian Sign Language (PISL, Hand Talk, Plains Sign Talk, First Nation Sign Language) [psd] (disabled)
- Blackfoot Sign Language
- Cree Sign Language
- Navajo (or Diné Family) Sign Language
- Ojibwa Sign Language